Recently published article on the mechanistic toxicology of Cyclosporin A and its effects on angiogenesis

November 26th, 2024, Vienna, Austria

A recent collaborative work within the framework of the in3 MSCA-ITN project has been recently published, showcasing the mechanistic toxicology of Cyclosporin A and its effects on angiogenesis!

Cyclosporin A (CSA) is a potent immunosuppressant, but its link to vascular dysfunction raises concerns. In this study we used induced pluripotent stem cells (iPSCs) to uncover the impact of CSA on endothelial cells, key players in vascular health. Findings revealed that CSA triggers oxidative stress by inducing reactive oxygen species (ROS) and impairing mitochondrial function, ultimately disrupting angiogenesis and blood vessel formation.

Additionally, an adverse outcome pathway (AOP) linking CSA exposure to vascular damage was developed, providing a valuable tool for predicting human toxicity.

Mazidi Z, Wieser M, Spinu N, Weidinger A, Kozlov AV, Vukovic K, Wellens S, Murphy C, Singh P, Lagares LM, Bobbili MR, Liendl L, Schosserer M, Diendorfer A, Bettelheim D, Eilenberg W, Exner T, Culot M, Jennings P, Wilmes A, Novic M, Benfenati E, Grillari-Voglauer R, Grillari J. Cyclosporin A toxicity on endothelial cells differentiated from induced pluripotent stem cells: Assembling an adverse outcome pathway. Toxicol In Vitro. 2024 Nov 14:105954. doi: 10.1016/j.tiv.2024.105954. Epub ahead of print. PMID: 39550010.