Recently published article on generating endothelial and vascular smooth muscle cells from PBMC and urine-derived iPSCs
November 4th, 2024, Vienna, Austria
A recent collaborative work with the Medical University of Vienna has been published exploring advancements in vascular tissue engineering. In this groundbreaking work, we have compared peripheral blood mononuclear cell (PBMC)-derived induced pluripotent stem cells (PiPSCs) and urine-derived induced pluripotent stem cells (UiPSCs) to assess their potential in generating endothelial cells (ECs) and vascular smooth muscle cells (VSMCs).
Both iPSCs successfully differentiated into functional ECs and VSMCs, with similar differentiation efficiencies. Notably, differentiated ECs demonstrated mature cell markers, morphology, and tube-forming abilities, and VSMCs exhibited characteristic markers and maintained typical vascular smooth muscle functionality.
Images were extracted from the original publication (Figures 2d and 5a) under the terms and conditions of the Creative Commons Attribution (CC BY) licence.